TEL AVIV — Teva Pharmaceutical Industries (TEVA.N) is to cut its workforce by more than a quarter, give up many of its manufacturing plants and suspend its dividend on ordinary shares in a much-anticipated overhaul to help pay off its debts.

The Israel-based company, the world's largest generic drugmaker, said on Thursday the move will result in a reduction of 14,000 jobs globally, with the majority to come in 2018.

The two-year restructuring plan is intended to reduce Teva's cost base by US$3 billion by the end of 2019, out of an estimated cost base for 2017 of US$16.1 billion.

Shares in Teva were up 14.6 per cent at US$18 in New York, but are down 53 per cent since January.

Investors will like this plan as most are focused on the near-term cost cuts and not the business outlook, Wells Fargo analyst David Maris said.

"However, in our view, the new CEO's [US]$3 billion cost-savings goal is larger than we had anticipated, and while this is more needed for survival versus optimization, it may also have significant negative effects to Teva's competitiveness," said Maris, who rates the shares "market perform".

Saddled with nearly US$35 billion in debt since acquiring Allergan's (AGN.N) Actavis generic drug business for US$40.5 billion, Teva made a series of changes after Kare Schultz joined as its new chief executive on Nov. 1.

In a letter to Israeli Prime Minister Benjamin Netanyahu, Schultz said action was needed to ensure Teva's future.

"It is clear that without taking drastic steps in the coming weeks and months, the company will be increasingly vulnerable to potential takeover by global financial institutions or activists with their own agendas and the risk is real," he said.

Teva expects a restructuring charge from the plan in 2018 of at least US$700 million, mostly to come in the second and third quarters and mainly related to severance costs. Additional charges may follow decisions on closures or divestment of plants, R&D facilities and office locations.

"A longer-term strategy will come later in the year, however, in the near term we must remain focused on cash-flow generation, short-term revenue and serving our debt," Schultz said in a letter to employees.

SERVICING DEBT

Investors and analysts have questioned how Teva will be able to service its debt in coming years.

In a conference call with analysts, Schultz said Teva would use cash flow to pay down debt, initially focusing on bank debt.

"We have no plans for raising new equity, short term or long term," he told Reuters in an interview.

The company also expects help next year from two new branded products — its migraine drug fremanezumab and Austedo, which treats abnormal, involuntary movements associated with Huntington’s disease.

In the U.S. generics market, which has suffered from price declines in the past year, Schultz expects further price erosion overall in 2018.

This has led to some products becoming unprofitable. Teva is now determining which products it can adjust the price for and which products it "needs to get out of". Despite the consolidation, Schultz said he is confident Teva can remain competitive because of its broad portfolio of generic drugs.

Some 1,700 jobs will be cut and a manufacturing site will be closed in Israel, where the main labor federation threatened to hold a half-day general strike on Sunday, the start of the Israeli work week, in protest at the layoffs.

Schultz said Teva will maintain its headquarters in Israel.

The government went into damage-control mode ahead of Teva's announcement, including a telephone call from Netanyahu to Schultz, asking that he keep layoffs in Israel to a minimum.

Economy Minister Eli Cohen said Teva's employees should not pay for the company's failed investments abroad.

"Teva has succeeded thanks to grants and tax benefits it received from the state and thanks to developments by Israeli scientists," he said, adding: "We will fight for every employee."

The company said dividends on convertible preferred shares would be evaluated on a quarterly basis.

Teva will provide its 2018 outlook in February.